Allocate $1 billion from the US Treasury to making loans in the amount of $10,000 to $100,000 to main street entrepreneurship.
Use the existing network of CDFIs (i.e, Neighborworks) and an incubator program like www.vilcap.com to allocate the funds. Vilcap lets the entreprenuers themselves choose who gets a loan - and entrepreneurs are much better at due diligence then investors or bankers.
We need to give all the little guys a chance to create 5-10 0r 50 jobs in their local entrepreneurial efforts. Large scale change, VC, innovation, patents etc... are irrelevant. Creative types and hustlers make things happen, and they only need a drop to catalyze change.